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Xiaobo Mao Lab
Neurology, Institute for Cell Engineering
Johns Hopkins Medical Institute
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Our research focuses on two core areas of Pathogenic Mechanisms of Prion-like Proteins in Neurodegeneration
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1. Prion-like Protein Dynamics in Neurodegeneration
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Elucidating the cell-to-cell transmission pathways of prion-like proteins (e.g. α-synuclein, tau)
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Dissecting the molecular mechanisms underlying intercellular propagation and induced neurotoxicity
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Exploring the impact of prion-like protein strains on disease phenotypes
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Examining neuroinflammatory processes triggered by prion-like protein pathology
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Investigating environmental factors that modulate prion-like protein aggregation and spreading
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2. Therapeutic Development for Prion Proteinopathies
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Developing nanobody-based therapies to disrupt prion-like protein aggregation and transmission
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Harnessing nanomaterials for improved targeting and delivery of therapeutics
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Screening and evaluating rejuvenator compounds to restore proteostasis and mitigate neurodegeneration
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Open Positions
We are seeking highly motivated researchers at all levels to join our team in unraveling the mechanisms of prion-like protein pathogenesis and developing novel therapeutics. Open positions include:
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Postdoctoral Fellows
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Graduate Students
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Undergraduate Students
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Visiting Scientists
If you are passionate about neurodegeneration research, please contact Dr. Xiaobo Mao to discuss opportunities.
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